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Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant
源自：
Stephen I. Alexander, M.B., B.S., Neil Smith, M.B., B.S., Min Hu, M.D., M.Med., Deborah Verran, M.B., Ch.B., Albert Shun, M.B., B.S., Stuart Dorney, M.B., B.S., Arabella Smith, M.B., B.S., Boyd Webster, M.B., Ch.B., Peter John Shaw, M.B., B.S., Ahti Lammi, M.B., B.S., and Michael O. Stormon, M.B., B.S.
SUMMARY
Complete hematopoietic chimerism and tolerance of a liver allograftfrom a deceased male donor developed in a 9-year-old girl, withno evidence of graft-versus-host disease 17 months after transplantation.The tolerance was preceded by a period of severe hemolysis,reflecting partial chimerism that was refractory to standardtherapies. The hemolysis resolved after the gradual withdrawalof all immunosuppressive therapy.
Complete hematopoietic chimerism and tolerance of a liver allograftfrom a deceased male donor developed in a 9-year-old girl, withno evidence of graft-versus-host disease 17 months after transplantation.The tolerance was preceded by a period of severe hemolysis,reflecting partial chimerism that was refractory to standardtherapies. The hemolysis resolved after the gradual withdrawalof all immunosuppressive therapy.
Source Information
From the Centre for Kidney Research (S.I.A., M.H.); the Children’s Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney (S.I.A., N.S., A. Shun, S.D., A. Smith, B.W., P.J.S., A.L., M.O.S.); and the Australian National Liver Transplant Unit (D.V., A. Shun, S.D., M.O.S.) — all in Sydney.
Address reprint requests to Dr. Stormon at the Department of Gastroenterology, Children’s Hospital at Westmead, Locked Bag 4001, 2145, Sydney, Australia, or at michaes6@chw.edu.au .
From the Centre for Kidney Research (S.I.A., M.H.); the Children’s Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney (S.I.A., N.S., A. Shun, S.D., A. Smith, B.W., P.J.S., A.L., M.O.S.); and the Australian National Liver Transplant Unit (D.V., A. Shun, S.D., M.O.S.) — all in Sydney.
Address reprint requests to Dr. Stormon at the Department of Gastroenterology, Children’s Hospital at Westmead, Locked Bag 4001, 2145, Sydney, Australia, or at michaes6@chw.edu.au .
N Engl J Med 358:369, January 24, 2008