Authors: Tae-Il Jeon, Bing Zhu, Jarrod L. Larson, Timothy F. Osborne

Bitter taste–sensing G protein–coupled receptors (type 2 taste receptors [T2Rs]) are expressed in taste receptor cells of the tongue, where they play an important role in limiting ingestion of bitter-tasting, potentially toxic compounds. T2Rs are also expressed in gut-derived enteroendocrine cells, where they have also been hypothesized to play a role in limiting toxin absorption. In this study, we have shown that T2R gene expression in both cultured mouse...

J. Clin. Invest. doi:10.1172/JCI36461.